Abstract: Based on the study of RBF and its interpolating function, an information transfer model of a fluid-structure interaction (FSI) is build using RBF interpolating function. By program development, the fluid structure interaction analysis of each time step is performed on the Space Structure Automatic Analysis and Design System (AADS) of Tongji University, and the result of AADS is very close to the result of ADNIA software. The example analysis shows that RBF can be taken as an effective data exchange method and used to analyze a 3D FSI problem.