Abstract: The parameter sensitivity analysis of the wind-induced response of a long-span roof is performed in order to quantify the strength and relevance of the inputs in determining the variation in a wind-induced response. The propagation law of uncertainty between a wind load and a wind-induced response is discussed. First, repeated wind tunnel tests are carried out to obtain a large amount of fluctuating wind pressure time histories, which could be the input variable of sensitivity analysis. Then probability-statistic models of structural parameters are constructed reasonably. The parameter sensitivities to wind-induced responses are systematically analyzed by combining the Sobol' method and Latin hypercube sampling technique. It is found that the extreme wind-induced response approximately obeys a generalized extreme-value distribution. The uncertainty of wind-induced responses is mainly controlled by wind load uncertainty. The parameter sensitivity to a wind-induced response is related to the ratio of the resonant response to the total response. The sensitivity value is larger with the increase of the ratio.