Abstract: In order to study the stress and deformation characteristics of a large-scale wind turbine tower under stochastic wind loads, the time-history curve of fluctuating wind was simulated by an AR model. Based on an ABAQUS co-simulation platform, fluid-solid interaction analysis was carried out on wind turbine. Thus, the internal force and deformation of a wind turbine tower were obtained, and contrast analysis was made among calculated and monitored results. Research shows that the maximum stress is concentrated on the connected section of the bottom and middle tower, while no obvious stress concentration is found because of the perpendicularity between doorway axis and the prevailing wind direction, and the door frame being installed. It will cause the deviation of the maximum stress controlling points by ignoring the wind load on the tower. The results calculated by FSI method considering fluctuating agree well with the measured results. Therefore, it can accurately reflect internal forces and displacement variation characteristics with time.