Abstract: Based on large eddy simulation, the wind pressure on the surface of standard low-rise building model TTU at a scale of 1:50 was numerically simulated through computational fluid dynamics software Fluent. At the same time, the wind tunnel test of TTU model with the same scale was carried out. The results of numerical simulation were compared with those obtained from the wind tunnel test and the field observation. The comparisons showed that the mean and dynamic pressure distribution on the model surface obtained by LES simulation is in good agreement with the results from the wind tunnel test and field observation. Thus, large eddy simulation combined with a scaled model can be used to predict the dynamic wind pressures on full-scale low-rise building with no Reynolds number effect.