Abstract: Strong wind is not only the control factor for the design of long-span bridges but also a significant factor affecting the driving safety of vehicles on the bridge. The aerodynamic characteristic of vehicles is the premise for studying the driving safety of vehicles. The aerodynamic parameters of motor industry research association (MIRA) cars and heavy trucks under cross wind were calculated based on the computational fluid dynamics (CFD) simulation platform in this paper. The variation of the aerodynamic coefficient of vehicles with the wind yaw angle is studied when typical vehicles are located in different lanes on a bridge. The wind sheltering effects between heavy trucks and MIRA cars were also studied. The influence of the relative positions of vehicles on the wind sheltering effects was studied. The results show that the types of vehicles or their locations on different lanes of the bridge have different degrees of influence on the aerodynamics of the vehicles. Heavy trucks have obvious wind sheltering effect on MIRA cars. The aerodynamics of MIRA cars change significantly with the variation of the relative locations of vehicles and the aerodynamics of heavy trucks do not change so much.