Abstract: To analyze the influence of soil spatial variability in the liquefiable site on the uplift response of the pipe, upon the Cholesky decomposition technique with midpoint discretization, the density ratio of soil is regarded as a random field variable, and the two-dimensional random finite element computation is carried out based on OpenSees. The influence of soil spatial variability is analyzed on the random statistical characteristics of pipe uplift displacement and pipe uplift fragility. The results show that: when the pipe uplift displacement is large, the mean value of the pipe uplift displacement is smaller than the deterministic analysis result considering soil spatial variability, and the difference becomes more significant with the increase of spatial variability; the existence of local denser zones restrains the development of the severe uplift behavior of the pipe to a certain extent; the cumulative absolute velocity CAV can better characterize the effect of ground motion intensity on the pipe uplift displacement; the dispersion of the fragility function increases with the increase of soil spatial variability and is greater than the corresponding deterministic deviation, resulting in a flatter fragility curve; and the random variable model can not reasonably characterize the effect of spatial variability on the pipe uplift response.