Abstract: Vehicles traveling on long-span bridges are highly susceptible to crosswinds. As vehicles overtaking on a bridge deck, the aerodynamic interferences between the adjacent overtaking vehicles may give rise to a sudden change of aerodynamic loads acting on the vehicles, which could seriously affect the driving safety of vehicles. Taking a large container trailer and a van as examples, the aerodynamic characteristics of vehicles during the overtaking process are available by means of segment wind tunnel tests under tow different vehicle layouts. Considering the influence of the transient abrupt effect of the aerodynamic loads on the dynamic responses of vehicles, a relatively complete wind-vehicle-bridge coupling vibration analysis framework is established. The dynamic response characteristics of overtaking vehicles are investigated under various affected factors such as vehicle layout, wind velocity and vehicle speed. It focuses on the driving safety issues for the overtaking vehicles under crosswind, which are evaluated by the introduced safety indicators including dimensionless load transfer rate (LTR) and sideslip safety factor (SSF). The results show that the aerodynamic interference between the overtaking vehicles causes a large fluctuation of the aerodynamic loads for leeward vehicle during the overtaking process. With the increase of wind speed and vehicle speed, the LTR and SSF of vehicles gradually show a non-linear growth trend. The driving safety depends on the vehicle type. Vans are more likely to suffer rollover accidents, while large trailers are easier to suffer sideslip accidents.