Abstract: In order to explore the influence of construction disturbance and groundwater on the zonal disintegration of anchored surrounding rock, it takes the anchored surrounding rock in deep buried chamber as the research object, considers the influence of disturbance damage and pore water pressure on the strength parameters in the surrounding rock, establishes a coordinated deformation mechanical analysis model for the bolt and the rock, based on the neutral point of the anchor during the zonal disintegration phenomenon in anchored surrounding rock. Inverted and analyzed are the partition thickness, zonal disintegration width, number of fracture zones and fracture moments of anchored surrounding rock under different disturbance damage and pore water pressure conditions. The results show that: There are multiple neutral points along the bolt during the fracture of anchored surrounding rock zone in deep buried chamber, and the position of each neutral point is closely related to the construction disturbance damage and pore water pressure; Construction disturbance and pore water pressure will aggravate the zonal disintegration phenomenon of anchored surrounding rock, which is manifested as the number of the zonal disintegration and, the width in each fracture zone increases with the increase of disturbance degree and pore water pressure; Construction disturbances and pore water will lead to the loss of the anchor preload, thereby aggravating the zonal disintegration phenomenon of anchored surrounding rock. Finally, the understanding is justified by case analysis, and the research results can provide a reference for the support design and optimization of the surrounding rock in deep buried chamber.