Abstract: The adoption of hybrid structures composed of concrete-filled steel tube (CFST) columns, steel beams, and light steel frames can reasonably apply light steel structures originally only suitable for low or multi-story buildings to high-rise buildings, and the reasonable optimization of the structural form of the light steel subframe and the connection method with the main structure is conducive to improving its assembly rate. To investigate the force performance of the new sleeve-type vertical connection node of the main and secondary structures in the "hinge-rigid joint" semi-frame connection scheme (scheme of hinged-rigid connection, SHRC) to release the axial force of the subframe columns, carried out were low-cycle reciprocating loading tests on three subframe light steel columns and main structural steel beam composite specimens, and analyzed were the force transmission mechanism and failure mode of the sleeve-type connection node. Based on the test results, the SHRC was further optimized, and a "fully hinged" connection scheme (scheme of fully hinged connection, SFHC) with higher assembly rate and more convenient construction was proposed. Finally, taking a demonstration project as an example, carried out is the strong earthquake nonlinear dynamic time history analysis of the high-rise CFST column-steel beam-light steel frame composite structure with SHRC and SFHC connection schemes, and compared are the differences in structural energy dissipation, in structural dynamic response, and in component performance state. The results show that the plastic energy dissipation, maximum inter-story drift angle, and vertex displacement amplitude of the composite structure slightly increase when the SFHC is adopted, compared with the SHRC , but both have a good seismic performance, verifying the rationality of using the "fully hinged" connection scheme for high-rise CFST.