Abstract: Taking a full-frame-supported thick-plate transfer high-rise building structure with 99.2 m height as the research object, a 5-storey model of 1∶5 scale with a height of 5.92 m was designed, including one collaborative loading system considering the action of overturning moment and horizontal loading. The quasi-static testing was carried out under the action from 6-degree minor, 7-degree minor & moderate & rare earthquakes. The crack and damage development were investigated. Discussed were the mechanical behaviors of energy dissipation, skeleton curve, secant stiffness and strain response. The results show that this system has a good seismic performance and a cooperative working mechanism. The reasonable damage mechanism can be found that the components above the transfer floor crack first and the whole full-frame-supported layer then crack, realizing the design concept of "Strong full-frame-supported layer and weak tower". The energy dissipation is significantly enhanced after the 7-degree moderate earthquake (0.15 g). The cumulative energy dissipation in 7-degree rare earthquake (0.15 g) is effectively increased, compared with that of 7-degree rare earthquake (0.10 g). During the whole loading process, the bearing capacity of the full-frame-supported layer shows well with small stiffness degradation.