Abstract: The structural configuration of pentagonal three-four-strut alternated cable dome has the following characteristics: firstly, an arbitrary isosceles pentagonal grid is used at the ridge of upper chord; secondly, it is different from the traditional tension integral conception of Fuller, in which there are inclined multi-strut at the upper and lower chord nodes, which expands the upper chord grid and improves the stability of the overall structure. According to the joint equilibrium equation, a simple method for calculating the prestressing mode of pentagonal three-four-strut alternated cable dome is proposed with inner hole, and the general calculation formula of internal force of prestressed cable strut is derived. The formula calculation generates exact solutions. Calculations of 60 cases are carried out for different parameters of the structure, such as the number of lower chord ring cables, rise-span ratio, position of lower chord nodes and structural thickness adjustment coefficient, and the effects of different parameters on the pretension distribution of cable dome are discussed. The results of multi-parameter sensitivity analysis show that the prestressing distribution of the structure is not sensitive to the rise-to-span ratio, while the thickness-to-span ratio, the number of lower chord loops and the horizontal radius coefficient of the lower chord nodes have a greater influence and should be considered when designing the structure. The study of this paper provides a new scheme for the selection and design of cable dome.