Abstract: The normal Real Time Hybrid Simulation test (RTHS) selects one part of one whole structure with easily understandable mechanical properties as the numerical substructure, and another part of physical model with complex mechanical properties as the experimental substructure. By keeping consistency of the boundary conditions such as force and displacement between two parts, information exchange is conducted during the RTHS test. In order to overcome the difficulty in evaluating the wind-induced vibration response of high-rise structures with tuned mass damper (TMD) systems in the wind tunnel test, a RTHS system with electric motor-driven shaking table was developed in this study. The feasibility of developed RTHS in the evaluation on the wind induced vibration control of TMD-structure system was verified by RTHS test on the Guangzhou New TV Tower with TMD. Since the time delay effect caused by system nonlinearity and other factors in the RTHS system proposed exists, an adaptive time series (ATS) delay compensation algorithm was introduced in order to obtain the good velocity tracking ability for RTHS system. The optimal parameters of the time delay compensation algorithm for the RTHS system proposed were obtained through experiments. On this basis, RTHS test was conducted to evaluate the wind-induced response of the Guangzhou New TV Tower with TMD by the ATS time delay compensation algorithm. Research results showed that the adaptive time delay compensation algorithm proposed could accurately achieve motion-path tracking and reduce errors due to time delay. The RTHS test with ATS time delay compensation algorithm can obtain more accurate experimental results than those from the RTHS test without time delay compensation algorithm embedded.