Abstract: Real-time hybrid simulation reduces the influence of scale effects effectively, which combines physical experiments with numerical simulations. Due to the limitations of real-time numerical solving capabilities, large-scale real-time hybrid simulations are currently unfeasible. In addition, communication between the numerical computing platform and the physical loading equipment requires additional programming, which increases the challenges of using real-time hybrid simulation. In this paper, GPU parallel real-time solving for numerical substructures is employed, and a numerical computation platform for real-time hybrid simulation is developed that integrates large-scale numerical solving capabilities and communication. A soil-structure interaction system is used for numerical simulation and physical experiments. The results show that the platform can meet the performance requirements of real-time hybrid simulation, achieving real-time solutions for degrees of freedom from 40,000 to 570,000 within a 20 minutes time step. The platform integrates numerical resolution with real-time communication, reducing operational complexity while significantly increasing the scale of real-time solutions for numerical substructures, which is conducive to the promotion and application of real-time hybrid simulation.