Abstract: As a balanced scheme of accuracy and cost, the reasonable interface connection method of multi-scale model of building structure can accurately ensure the load transfer and motion coordination between different scale models. However, simple, accurate and widely applicable interface simulation methods and connection devices are still the focus and difficulty in the study of structural multi-scale model tests. Rigid interface connections are often established in traditional interface connection methods, which can make the internal force of each node at the interface different from the prototype structure, resulting in model distortion. Thusly, a multi-scale model interface simulation method considering the similarity of multi-parameters of shear force, of axial force and, of bending moment is proposed. By decomposing the internal nodes at the interface, the internal force coupling between two neighbor nodes is established, and the axial force is decoupled into the shear force and bending moment provided together, supplemental moments also provide overturning moments as "overlapping domains". According to the internal force balance equations of each node, an interface improvement transfer matrix based on the multi-point constraint method is established, the internal force multi-parameter similarity of shear force, of axial force and, of bending moment of each node at the interface is achieved for the storey-component multi-scale model, the calculation method and procedure of the improved transfer matrix are proposed, and the multi-scale interface test model is established. Finally, a frame structure was selected as a typical test model, and a full component-scale prototype model and a storey-component multi-scale model were produced respectively, and the accuracy and feasibility of the method were verified by the shaking table tests and by the static tests under vertical and horizontal loads.