Abstract: The study of urban seismic resilience combines the risk analysis of earthquake disaster with the evaluation of urban seismic resilience, perfecting and expanding the theory and method of urban seismic safety resilience. Based on the theory of "risk source-risk exposure-mitigation factor", this paper adopts the probabilistic seismic hazard analysis and vulnerability for hazard bearing body as seismic risk assessment methods, introduces mitigation factor as an important evaluation index, constructs an evaluation model of urban seismic safety and resilience, and studies the seismic resilience level of some blocks in Beijing. The multi-source data of some blocks are used to calculate the multi-scenario earthquake risk and analyze the mitigation factor and evaluate the seismic safety resilience. Through z-score standardization, the study area is divided into four types: high risk-high mitigation factor, high risk-low mitigation factor, low risk-high mitigation factor, and low risk-low mitigation factor, with the differences between seismic resilience of the blocks being more clearly identified. The research results provide scientific basis for targeted urban earthquake prevention and disaster reduction, and have certain reference value for urban earthquake prevention and disaster reduction and resilient city construction.