Abstract: To address the issue of support unclipping failure in traditional standing seam metal roofing systems (SSMRS) with T-shaped support under strong winds, a novel support with double-sided clamped configuration is proposed. To investigate the wind uplift resistance and failure mechanism of this innovative system, full-scale static wind uplift tests were conducted, a refined FE model validated by test was established, and systematic parametric analysis was performed. The results indicate that typical failure modes of the system include local buckling of roof panels, bending of rib, plastic straightening of the curved support segment, and fuondation uplift. The wind uplift bearing capacity increases with greater roof panel thickness but decreases with larger panel width and support longitudinal spacing. The numerical model accurately reproduces the whole process failure mechanism from elastic deformation to straightening and unclipping of the curved segment. Based on experimental and numerical analyses, a prediction formula for wind uplift bearing capacity is established, showing good agreement with test and simulated values. The research provides theoretical basis and engineering reference for wind resistant design of high performance metal roofing systems.