Abstract: The interaction system, which includes pi1e-supported tall buildings and the adjacent medium of soil, subject to the impact of earthquake is formulated in terms of the spline subdomain method, semi-analytical infinite element method and the bend-shear model of beam element, respectively. Taking advantage of the instantaneous optimal control algorithm, structure -piles-soil interaction effect on the magneto-rheological (MR) damper control is considered. It is shown that the structure control generates obvious different results between the interaction system and the fixed-end system. The response of the former may be 5 percent or more than the latter. The dissipative capability of the structural self will be omitted largely if the interaction isn’t considered. To design the control system, especially for some tall buildings, soil-structure interaction should be taken into consideration.